- Original Article
- Epidemiologic and Clinical Features of
Pertussis in Children(2000. 3-2001. 3)
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Shin Yoo, Kyong Ouk Ahn, Eun Hye Park, Hyun Sang Cho, Chong Young Park, Hae Ran Lee
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Clin Exp Pediatr. 2002;45(5):603-608. Published online May 15, 2002
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Purpose : Pertussis is a highly communicable infectious disease in children with high mortality, especially in young infants. The incidence of pertussis in South Korea has decreased to about 10 cases a year in late '90s. Doubting previously reported incidences of pertussis, we designed this study to establish exact epidemiology and a diagnostic basis of pertussis.
Methods : From Mar. 2000... |
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- A Study of the Bystander Effect and Its Enhancement in
HSV-TK Gene Therapy Using a Murine Neuroblastoma Model
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Hyun Sang Cho, Moon Kyu Kim, Chong Young Park
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Clin Exp Pediatr. 2002;45(3):354-361. Published online March 15, 2002
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Purpose : Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We first investigated the bystander effect of retrovirus-mediated gene transfer of herpes simplex virus thymidine kinase(HSV-TK) gene to murine neuroblstoma cell line(neuro-2a) in vitro and in vivo. Second, we examined the mechanism and its enhancement of the bystander effect in murine neuroblastoma.
Methods... |
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- Tumor Vaccine Effect by IL-16 Gene Transfer into Murine Neuroblastoma Model
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Hyun-Sang Cho, Chong Young Park
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Clin Exp Pediatr. 2001;44(1):68-74. Published online January 15, 2001
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Purpose : Interleukin(IL)-16 is a potent chemoattractant factor for CD4+ T cells, monocytes, and eosinophils. It up-regulates IL-2R on CD4+ T lymphocytes and regulates the function of antigen presenting cells. We used retrovirus-mediated gene transfer of the human IL-16 gene into the neuro-2a cells, which is the murine neuroblastoma cell lines, to investigate whether locally secreted IL-16 might generate anti-tumor... |
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- Case Report
- A Case of T-cell Acute Lymphoblastic Leukemia presented with Spontaneous Tumor Lysis Syndrome and Superior Vena Cava Syndrome
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Eun Jung Shim, Hyun-Sang Cho, Jae Kook Cha, Jae Kook Cha, Chong Young Park
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Clin Exp Pediatr. 2000;43(7):974-977. Published online July 15, 2000
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Acute spontaneous tumor lysis syndrome is a condition resulting from the rapid release of cellular
breakdown products into the circulation due to massive cytolysis occurring before start of treatment.
It occurs most often in Burkitt' s lymphoma and T-cell ALL, both of which have been well
described, following cytotoxic chemotherpy and other single agent administrations. However, only a
handful of spontaneous acute tumor lysis... |
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- Original Article
- Effects of Hepatitis B Revaccination in Nonresponsive Children
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Ui Chong Chong, Mi Ran Kim, Chong Young Park
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Clin Exp Pediatr. 1999;42(6):778-782. Published online June 15, 1999
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Purpose : Hepatitis B virus infection is prevalent in Korea. Active immunization of Hepatitis B has been proceeded extensively for the last decade. This study was performed to estimate the negative rate of anti-HBs after immunization and to evaluate the effect of revaccination among Korean children between 1995 and 1997, as well as to determine a proper revaccination schedule.
Methods :... |
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- A Clinical Study on Acute Lower Respiratory Tract Infections by Adenovirus in Children
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Ui Chong Chong, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Han Sung Kim, Kyu Man Lee
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Clin Exp Pediatr. 1998;41(8):1070-1077. Published online August 15, 1998
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Purpose : This study was performed to characterize the epidemiologic and clinical features of acute adenoviral lower respiratory tract infections.
Methods : Culture and indirect immunofluorescence for adenovirus was done with nasopharyngeal aspirates from patients with acute lower respiratory tract infections from April to September, 1996. Cultured virus was serotyped for type 3, 4, and 7a by neutralization test, and medical... |
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- A Clinical Analysis on Acute Lower Respiratory Tract Infections in Children Caused by Influenza Virus in Children
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Kiehl Hyung Lee, Woo Kyung Kim, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Kyu Man Lee
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Clin Exp Pediatr. 1998;41(12):1623-1631. Published online December 15, 1998
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Purpose : Although annual epidemics occur, there are only a few clinical studies on influenza in Korea. We evaluated the epidemic and clinical features of acute lower respiratory tract infections in children by influenza virus.
Methods : From Feb., 1995 to July, 1997, influenza virus isolations and clinical review were performed on hospitalized children with acute lower respiratory tract infections at... |
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- Epidemiologic and Clinical Feature of Acute Lower Respiratory Tract Infections by Respiratory Syncytial Virus and Parainfluenza Virus in Children
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Jeoung Jin Lee, Hyeon Seon Park, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Woo Kap Chung, Kyu Man Lee
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Clin Exp Pediatr. 1997;40(8):1071-1080. Published online August 15, 1997
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Purpose : This is to analyze epidemic and clinical features of acute respiratory tract infections(ALRTI) by respiratory syncytial virus(RSV) and parainfluenza virus(PIV), which are considered to be the major respiratory pathogens in children.
Methods : Nasopharyngeal aspirates were collected from 515 patients with ALRTI hospitalized at Hangang Sacred Heart Hospital between Apr. ’94 and Oct. ’96. Nasopharyngeal aspirates were inoculated to... |
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- Report of Nationwide Epidemiology of Aseptic Meningitis Outbreak in 1993 in Korea
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Sung Hee Oh, Moo-Song Lee, Jin Han Kang, Chang Hwi Kim, Chong Young Park, Young Mo Sohn, Hoan Jong Lee, Chung Sik Chun, Sang Mann Shin
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Clin Exp Pediatr. 1996;39(1):42-52. Published online January 15, 1996
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Purpose : There has been no nationwide report pertaining to the epidemiology of aseptic meningitis, although a great numer of patients have been diagnosed of the illness. Therefore, we report an explosive outbreak of aseptic meningitis occured in a nationwide scale in 1993.
Methods : Aseptic meningitis epidemiology surveillence was performed retrospectively on the patients diagnosed of aseptic meinigitis from January... |
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- Epidemiology and Vaccine Efficacy of Measles During the 1993 measles Epidemic
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Soon Ki Kim, Jong Woon Choi, Byong Kwan Son, Seung Nam Park, Churl Young Chung, Young Min Ahn, Chong Young Park, Ki Yang Ryoo, Woo Kap Chung, Hoan Jong Lee
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Clin Exp Pediatr. 1995;38(6):778-785. Published online June 15, 1995
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Purpose : Because of increased measles incidence in Korea during 1993 and the recent finding of genomic differences between vaccine virus and contemporary wild measles viruses, we conducted a measles vaccine efficacy study involving children ages 1 to 5 yeark, with the demographic analysis of patients brought to the hospitals during measles outbreak that had occurred 1993 in Seoul and... |
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- Immunogenicity and Safety of Live Attenuated Vaccine(MAV/06srtain) on Healthy Children and Immunocompromised Children
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Young Mo Sohn, Chul Joo Yu, Pyung Kil Kim, Kir Young Kim, Chong Young Park, Mi Ran Kim, Woo Kap Jeung, Kyu Kye Hwang, Gyu Jin Woo, Song Yong Park
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Clin Exp Pediatr. 1995;38(6):771-777. Published online June 15, 1995
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Purpose : To study the safety and immunogenicity of new live attenuated varicella vaccine (MAV/06strain) in normal healthy children and immunocompromized children in Korea.
Methods : Blood samples for fluorescent antibody to membrane antigen(FAMA) assay were taken before the vaccination among seven hundred forth five healthy children and twenty two nine immunocompromised children. One hundred and seventy seven children and twenty... |
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- Case Report
- Familial Erythrophagocytic Lymphohistiocytosis in Siblings
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Eun Sook Lee, Ji Eun Choi, Dug Ha Kim, Hae Ran Lee, Chong Young Park
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Clin Exp Pediatr. 1995;38(3):428-434. Published online March 15, 1995
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Familial erythrophagocytic lymphohistiocytosis(FEL) is an uncommon disorder characterized by multi-organ infiltration with phagocytic histiocytes and macrophages. It is a familial discorder presenting during infancy or young childhood with fever, hepartosplenomegaly, pancytopenia, bleeding diathesis, hypertriglyceridemia and neurologic manifestations. The course of the disease is extremely lethal and diagnosis of the disease during lifetime is very difficult. Exact diagnosis can only be... |
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- Original Article
- Role of Adenovirus in Diarrheal Children
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Gyung Ok Yu, Young Bae Moon, Dong Rak Choi, Duk Ha Kim, Hae Ran Lee, Chong Young Park, Hee Jung Kang, Kyu Man Lee
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Clin Exp Pediatr. 1994;37(2):205-211. Published online February 15, 1994
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In order to investigate the role of adenovirus in diarrheal children, we evaluated 907 children with diarrhea and 193 children without diarrhea for a 22-month. Stools were tested for group A rotavirus antigen and for adenovirus types 40/41 (Ad 40/41) by using ELISA, cell technique and indirect immunofluorescent method. Adenovirus was detected in 10.1% of the diarrheal children and 3.1%... |
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- Case Report
- A Case of Aicardi Syndrome with Cleft Lip and Palate
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In Seok Yang, Gyung Og Yu, Soo Ahn Chae, Dug Ha Kim, Chong Young Park, Ik Won Kang
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Clin Exp Pediatr. 1993;36(9):1325-1330. Published online September 15, 1993
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A case of Aicardi syndrome with cleft lip and palate was experienced at the Department of Pediatrics, College of Medicine, Hallym University, and the patient's infantile spasm was treated with ACTH. In previous studies, four cases of Aicardi syndrome accompanied by cleft lip and palate were reported. We present the fifth case of Aicardi syndrome with cleft lip and palate... |
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- A Case of Ritter's Disease
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Young Kul Lee, Eun Mi Kim, Dong Rak Choi, Hae Ran Lee, Chong Young Park
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Clin Exp Pediatr. 1992;35(6):840-844. Published online June 15, 1992
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Ritter's disease, or staphylococcal scalded skin syndrome, is a form of skin disease due to the exfoliative toxin, exfoliatin, produced by various species of staphylococci and is characterized by generalized bullae formation and exfoliation.
The authors experienced a case of Ritter's disease in an 8 day-old newborn who had generalized bullae and skin exfoliation. Unfortunately, the patient expired on the 13th... |
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- Original Article
- Hepaplastin Test for Screen of Vitamin K Deficiency in Term and Preterm Neonates
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Eun Mi Kim, Gyung Og Yu, Dong Rak Choi, Chong Young Park, Hae Ran Lee, Choon Myung Ro
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Clin Exp Pediatr. 1992;35(5):614-620. Published online May 15, 1992
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To screen vitamin K deficiency in term and preterm neonates, the authors conducted Hepaplastin test based on 40 term and 40 preterm neonates who were delivered at Han Gang Sacred Heart Hospital. Also we compared Hepaplastin activity of term neonates with that of preterm neonates. 0.5mg or 1mg of vitamin K1 was injected intramuscularly immediately after birth according to the... |
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- A clinical study on meconium-stained babies.
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Cheol Ki Min, Sung Suk Bang, Chong Young Park, Hae Ran Lee, Choon Myung Ro
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Clin Exp Pediatr. 1991;34(1):24-30. Published online January 31, 1991
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Among a total of 667 newborns delivered at Han Gang Sacred Heart Hospital from January 1988
to July 1989, a clinical study was done regarding meconium-stained babies.
The results were summarized as follows:
1) The incidence of meconium staining was 25.9% (173 babies) and there was no difference of
frequency in sex.
2) The higher the birth weigt and the gestational age, the higher the incidence of... |
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- A Clinical Study on Neonatal seizures.
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Chong Young Park, Myung Kul Yun, Jung Hwan Choi, Yong Seung Hwang, Chong Ku Yun
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Clin Exp Pediatr. 1985;28(3):225-235. Published online March 31, 1985
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Clinical Observations were made on 96 cases of neonatal seizure who were admitted to the Department of Pediatrics, Seoul National University Hospital during the period of 5 years from June, 1979 to May, 1984.
The results were as follows: 1)The most frequent cause of neonatal seizure was sepsis with or without meningitis
(27.4%), and followed by hypocalcemia(23.4%)> hypoxic-ischemic brain damage(12.9%), hypoglycemia(8.0%), intracranial... |
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